July 11, 2019
New ALEX publication available
Extract and component-specific sensitization patterns in Canadian moderate-to-severe preschool asthmatics (Allergy 2019, Hoang et al.)
In this study by the Canadian institution Hospital for Sick Children (Toronto), 87 pre-school children with moderate-to-severe Asthma were screened for sensitizations with ALEX and skin-prick tests. 67% of those children displayed allergic sensitizations. The most prominent allergen sources detected were peanut (35%), cat (29%), tree-nuts (20-29%), dog and soy (25%) and hen’s egg(24%).
Peanut and cat sensitizations showed the strongest association with clinical surrogate markers of uncontrolled asthma. For Fel d 1, the major allergen from cat, an association with atopic dermatitis was present. This may suggest that the skin is an important sensitization route for this allergen.
Visits to emergency departments and usage of oral corticosteroids were associated with sensitizations to the seed storage proteins from legumes and tree-nuts (peanut: Ara h 1,2,3,6; soy: Gly m 6; hazelnut: Cor a 9, 11, 14) plus sensitizations to the major cat and dog allergens Fel d 1 and Can f 1.
Conclusion: peanut and animal allergens from cat and dog were major allergen sources in the investigated population. Seed storage proteins, as well as Fel d 1 (cat) and Can f 1 (dog) demonstrated the strongest link to clinical markers of asthma severity.
This publication is not open access: https://www.ncbi.nlm.nih.gov/pubmed/31125434
July 11, 2019
New ALEX publication available
Comparison of two multiplex arrays in the diagnostics of allergy (Clinical and Translational Allergy 2019, Bojcukova et al.)
The aim of the study was to compare the performance between MADx ALEX with ImmunoCAP ISAC for the most prevalent molecular allergens in the region of Plzen (Czech Republic): Bet v 1 (birch pollen), Phl p 1&5 (timothy grass pollen), Der p 1&2 (house dust mite) and Fel d 1 (cat). In total 198 patients were tested with both systems.
Correlation coefficients (r) were highly significant for every comparison with a range for r from 0.91 (Fel d 1) to 0.95 (Bet v 1), with the other molecular allergens in between.
The Cohen kappa statistic (κ) analysis showed very good agreement (κ>0.81) between the two test methods for the analysed molecular allergens. The κ value was lowest for Fel d 1 (0.83) and highest for Der p 2 (0.91), with the other molecular allergens in between.
All negative control-sera (n=16) showed no IgE-reactivity in both systems.
Conclusion: Despite technical differences, the results showed a substantial agreement between the two methods, similar to other published studies (Heffler 2018, Buzzulini 2019).
This publication is open access: https://ctajournal.biomedcentral.com/articles/10.1186/s13601-019-0270-y
May 21, 2019
MADx wins global start up award!
MADx participated in the 3rd start-up launchpad investment competition at Asia's largest tech trade show in Hong Kong – Startup Launchpad.
Among 200 competing companies, MADx was chosen by the jury as the most promising candidate based upon the business case, solution orientation, management skills and clarity of presentation.
The awarded prizemoney of 40k€ is a welcome addition to our R&D budget.
May 21, 2019
EAACI, Portugal, June 1st-5th (Booth D17)
The annual meeting of the European Academy of allergology and clinical immunology is an almost mandatory event for all clinicians and researcher in the field of allergology.
Please visit us at our booth at the EAACI in Lisbon. We will present the prototype of our newly developed automated ALEX laboratory instrument and will reveal more information about the upcoming ALEX version 2. See you in Lisbon!
Grazer Allergietag, Austria, September 14th
For the 24th year in a row the working group allergology of the Austrian society of dermatology is organizing this high-level allergy symposium. See you in Graz!
SEAIC, Spain, October 23rd-26th
The annual meeting of the Spanish society of allergology and clinical immunology will be held in Gran Canaria this year. The focus will be on cutaneous allergy, but also molecular allergology will be an important topic. Please visit our booth & see you in Gran Canaria!
ISMA, Netherlands, November 28th-30th
This is the perfect place for all professionals interested in molecular allergology. We will present performance data on some of the new ALEX version 2 molecular allergens. Please visit us at our booth & see you in Amsterdam!
April 30, 2018
First ALEX publication now available!
The world allergy organization journal published the first study that investigated the performance of ALEX. The research group, centred on Enrico Heffler and Giovanni Melioli, describes the unique diagnostic features of ALEX and compares the performance of ALEX vis a vis ImmunoCAP® ISAC.
The paper is open access and available here
More ALEX studies are on their way and will be published soon!
April 9, 2018
MADx awarded 2.5 Mio € by the EU
Macro Array Diagnostics was selected as the only Austrian life science company to receive 2.5 Mio € within the EU’s Horizon 2020 (small- and medium enterprise) funding programme. This is the highest amount of EU funding any Austrian company has ever received. We are very happy and proud about this success in a highly selective application and review process.
The funds will be used to speed up the development of the revolutionary ALEX® – Allergy Explorer test platform and to develop an automated processing solution for medical laboratories.
November 23, 2017
MADx wins international Best of Biotech award
Among 30 participating companies, MADx was chosen by the jury of the Best of Biotech (BoB) award as one of the most promising start-up companies in 2017.
The prestigious BoB award is funded by industry giants like Roche or Shire and supported by the Austrian Federal government. (http://www.bestofbiotech.at).
November 10, 2017
Thanks to all who visited our booth and our poster presentation at the ISMA in Luxembourg this year.
For all who are interested in the poster about the CCD antibody blocking capabilities of ALEX, please click here to download.
See you at the EAACI 2018 in Munich!
October 25, 2017
Custom Array Service now available!
We are happy to announce that from now on we offer the MADx custom array service. To support your research endeavours, we offer to produce arrays of selected ALEX allergens combined with your own allergen preparations.
If you are interested in the custom array service, please contact us.
October 2, 2017
Alex - now available!
We are happy to announce that the Allergy Explorer (ALEX®) test kit is now CE marked and available as an IVD product.
ALEX is the first in vitro multiplex allergy test that offers:
- Simultaneous measurement of total and specific IgE
- A near complete allergen panelIntegrated CCD inhibition
- Flexible software to create on-demand allergen panel