Summary:
The present publication investigates the role of the nasal microbiome in individuals with non-steroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (NERD). The study aims to shed light on the potential influence of the nasal microbiome in NERD patients without corticosteroid therapy, as the microbiome plays a vital role in respiratory health and inflammation. NERD is a condition characterized by the exacerbation of respiratory symptoms, such as asthma and rhinitis, upon the use of NSAIDs. The ALEX2 Allergy Xplorer was used to determine the IgE sensitisation profile of each patient in the blood. The research team collected nasal swabs of all patients. These swabs were then analyzed to identify and compare the composition of the nasal microbiota between the two groups (NERD patients and healthy control group). The findings of the study revealed significant differences in the nasal microbiome composition. NERD patients exhibited alterations in the abundance and diversity of nasal microbial communities, suggesting a potential dysbiosis or imbalance in their nasal microbiota. Furthermore, the study highlighted specific bacterial taxa that were significantly associated with NERD. These findings provide insights into the potential role of certain bacterial species or groups in NERD pathogenesis and may have implications for future diagnostic and therapeutic approaches.
Front Immunol. 2023 Apr 14;14:1112345. doi: 10.3389/fimmu.2023.1112345. PMID: 37122714; PMCID: PMC10140405.